Leukothera™ is a natural targeted biologic that is specific for a subset of white blood cells (WBCs).  The agent functions by depleting and preventing migration of the activated immune cells involved in diseases of white blood cells.  The cellular receptor for Leukothera™ is leukocyte function antigen-1 (LFA-1).  Since LFA-1 is expressed only on WBCs, other cells and tissues of the body are not affected.

Competitive advantages for Leukothera™ include:

1. •Targeted – Bacause of its specificity for activated LFA-1, Leukothera™ only targets certain WBCs.
   

1. •Dual mechanism of action – Leukothera™ is able to both kill diseased WBCs and prevent them from migrating to other parts of the body.
   

1. •Highly active – Leukothera™ is a natural agent that evolved to target only WBCs.  Thus, doses of Leukothera™ required to deplete susceptible cells are significantly lower than for other biologics such as monoclonal antibodies.
   

1. •Safe – Leukothera™ administered to rhesus monkeys caused transient depletion of only WBCs and was well tolerated with no observed adverse reactions.
   

1. •Easily manufactured – Leukothera™ is naturally secreted in high purity and abundance by an oral bacterium.  This eliminates the need for time-consuming and costly purification steps.
   

Click below to learn about the use of Leukothera™ for treatment of various diseases:

1. •Hematologic malignancies
   

1. •Autoimmune diseases
   

1. •HIV infection